.pdufa-card[data-astro-cid-ovbiwbkw]{border-top:1px solid var(--c-rule);padding:22px 0 24px;font-family:var(--f-ui)}.pdufa-card[data-astro-cid-ovbiwbkw][hidden]{display:none}.pdufa-stripe[data-astro-cid-ovbiwbkw]{font-family:var(--f-mono);font-size:10px;letter-spacing:.22em;text-transform:uppercase;color:var(--c-muted);margin-bottom:14px;display:flex;align-items:baseline;gap:8px;flex-wrap:wrap}.pdufa-date[data-astro-cid-ovbiwbkw]{color:var(--c-dark);font-weight:600}.pdufa-divider[data-astro-cid-ovbiwbkw]{color:var(--c-rule)}.pdufa-status-label[data-astro-cid-ovbiwbkw]{color:var(--c-rust);font-weight:600}.pdufa-status-approved[data-astro-cid-ovbiwbkw] .pdufa-status-label[data-astro-cid-ovbiwbkw]{color:var(--c-accent)}.pdufa-status-crl[data-astro-cid-ovbiwbkw] .pdufa-status-label[data-astro-cid-ovbiwbkw],.pdufa-status-rtf[data-astro-cid-ovbiwbkw] .pdufa-status-label[data-astro-cid-ovbiwbkw],.pdufa-status-withdrawn[data-astro-cid-ovbiwbkw] .pdufa-status-label[data-astro-cid-ovbiwbkw]{color:var(--c-rust)}.pdufa-status-extended[data-astro-cid-ovbiwbkw] .pdufa-status-label[data-astro-cid-ovbiwbkw]{color:var(--c-gold)}.pdufa-days[data-astro-cid-ovbiwbkw]{color:var(--c-muted)}.pdufa-title[data-astro-cid-ovbiwbkw]{margin:0 0 6px;font-size:24px;font-weight:700;letter-spacing:-.01em;color:var(--c-dark);line-height:1.25;display:flex;flex-wrap:wrap;gap:8px;align-items:baseline}.pdufa-sponsor[data-astro-cid-ovbiwbkw]{font-weight:700}.pdufa-ticker[data-astro-cid-ovbiwbkw]{font-family:var(--f-mono);font-size:11px;letter-spacing:.16em;color:var(--c-muted);font-weight:500;vertical-align:middle}.pdufa-emdash[data-astro-cid-ovbiwbkw]{color:var(--c-rule);font-weight:400}.pdufa-drug[data-astro-cid-ovbiwbkw]{color:var(--c-rust);font-weight:600}.pdufa-brand[data-astro-cid-ovbiwbkw]{color:var(--c-muted);font-weight:500;font-size:18px}.pdufa-indication[data-astro-cid-ovbiwbkw]{margin:0 0 14px;font-size:15px;color:var(--c-mid);font-style:italic}.pdufa-meta[data-astro-cid-ovbiwbkw]{margin:0 0 8px;font-family:var(--f-mono);font-size:11px;letter-spacing:.14em;text-transform:uppercase;color:var(--c-accent);display:flex;flex-wrap:wrap;gap:6px;align-items:baseline}.pdufa-apptype[data-astro-cid-ovbiwbkw]{color:var(--c-dark);font-weight:600}.pdufa-designation[data-astro-cid-ovbiwbkw]{color:var(--c-accent);font-weight:500}.pdufa-des-priority-review[data-astro-cid-ovbiwbkw],.pdufa-des-breakthrough[data-astro-cid-ovbiwbkw]{color:var(--c-rust);font-weight:600}.pdufa-context[data-astro-cid-ovbiwbkw],.pdufa-outcome[data-astro-cid-ovbiwbkw]{margin:0 0 8px;font-size:14px;color:var(--c-mid);line-height:1.5}.pdufa-outcome[data-astro-cid-ovbiwbkw]{padding:8px 0 8px 12px;border-left:2px solid var(--c-rust);margin-top:10px}.pdufa-status-approved[data-astro-cid-ovbiwbkw] .pdufa-outcome[data-astro-cid-ovbiwbkw]{border-left-color:var(--c-accent)}.pdufa-sources[data-astro-cid-ovbiwbkw]{margin:12px 0 0;font-family:var(--f-mono);font-size:11px;letter-spacing:.16em;text-transform:uppercase}.pdufa-sources[data-astro-cid-ovbiwbkw] a[data-astro-cid-ovbiwbkw]{color:var(--c-accent);border-bottom:1px solid currentColor;padding-bottom:1px;transition:color .15s}.pdufa-sources[data-astro-cid-ovbiwbkw] a[data-astro-cid-ovbiwbkw]:hover{color:var(--c-dark)}.pdufa-main[data-astro-cid-x2hdbyyw]{padding:36px 48px 60px;min-width:0}.pdufa-header[data-astro-cid-x2hdbyyw]{padding-bottom:24px;margin-bottom:16px}.pdufa-eyebrow[data-astro-cid-x2hdbyyw]{font-family:var(--f-mono);font-size:11px;letter-spacing:.28em;text-transform:uppercase;color:var(--c-rust);font-weight:600;margin:0 0 12px}.pdufa-h1[data-astro-cid-x2hdbyyw]{font-family:var(--f-ui);font-size:clamp(48px,6vw,88px);font-weight:800;line-height:.88;letter-spacing:-.03em;color:var(--c-dark);margin:0 0 16px}.pdufa-deck[data-astro-cid-x2hdbyyw]{font-family:var(--f-ui);font-size:17px;color:var(--c-mid);line-height:1.55;margin:0;max-width:720px}.pdufa-list[data-astro-cid-x2hdbyyw]{border-bottom:1px solid var(--c-rule)}@media(max-width:880px){.pdufa-main[data-astro-cid-x2hdbyyw]{padding:24px 24px 60px}}@media(max-width:700px){.pdufa-main[data-astro-cid-x2hdbyyw]{padding:24px 20px 60px}.pdufa-h1[data-astro-cid-x2hdbyyw]{font-size:56px}}